AustralieFrV1, Main, Exploration, bibRecord, 002503

RAD51B in Familial Breast Cancer

Identifieur interne : 002503 ( Main/Exploration ); précédent : 002502; suivant : 002504

RAD51B in Familial Breast Cancer

Auteurs : Liisa M. Pelttari [Finlande] ; Sofia Khan [Finlande] ; Mikko Vuorela [Finlande] ; Johanna I. Kiiski [Finlande] ; Sara Vilske [Finlande] ; Viivi Nevanlinna [Finlande] ; Salla Ranta [Finlande] ; Johanna Schleutker [Finlande] ; Robert Winqvist [Finlande] ; Anne Kallioniemi [Finlande] ; Thilo Dörk [Allemagne] ; Natalia V. Bogdanova [Allemagne] ; Jonine Figueroa [États-Unis] ; Paul D. P. Pharoah [Royaume-Uni] ; Marjanka K. Schmidt [Pays-Bas] ; Alison M. Dunning [Royaume-Uni] ; Montserrat García-Closas [États-Unis, Royaume-Uni] ; Manjeet K. Bolla [Royaume-Uni] ; Joe Dennis [Royaume-Uni] ; Kyriaki Michailidou [Royaume-Uni] ; Qin Wang [Royaume-Uni] ; John L. Hopper [Australie] ; Melissa C. Southey [Australie] ; Efraim H. Rosenberg [Pays-Bas] ; Peter A. Fasching [Allemagne, États-Unis] ; Matthias W. Beckmann [Allemagne] ; Julian Peto [Royaume-Uni] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; Elinor J. Sawyer [Royaume-Uni] ; Ian Tomlinson [Royaume-Uni] ; Barbara Burwinkel [Allemagne] ; Harald Surowy [Allemagne] ; Pascal Guénel [France] ; Thérèse Truong [France] ; Stig E. Bojesen [Danemark] ; B Rge G. Nordestgaard [Danemark] ; Javier Benitez [Espagne] ; Anna González-Neira [Espagne] ; Susan L. Neuhausen [États-Unis] ; Hoda Anton-Culver [États-Unis] ; Hermann Brenner [Allemagne] ; Volker Arndt [Allemagne] ; Alfons Meindl [Allemagne] ; Rita K. Schmutzler [Allemagne] ; Hiltrud Brauch [Allemagne] ; Thomas Brüning [Allemagne] ; Annika Lindblom [Suède] ; Sara Margolin [Suède] ; Arto Mannermaa [Finlande] ; Jaana M. Hartikainen [Finlande] ; Georgia Chenevix-Trench [Australie] ; Laurien Van Dyck [Belgique] ; Hilde Janssen [Belgique] ; Jenny Chang-Claude [Allemagne] ; Anja Rudolph [Allemagne] ; Paolo Radice [Italie] ; Paolo Peterlongo [Italie] ; Emily Hallberg [États-Unis] ; Janet E. Olson [États-Unis] ; Graham G. Giles [Australie] ; Roger L. Milne [Australie] ; Christopher A. Haiman [États-Unis] ; Fredrick Schumacher [États-Unis] ; Jacques Simard [Canada] ; Martine Dumont [Canada] ; Vessela Kristensen [Norvège] ; Anne-Lise Borresen-Dale [Norvège] ; Wei Zheng [États-Unis] ; Alicia Beeghly-Fadiel [États-Unis] ; Mervi Grip [Finlande] ; Irene L. Andrulis [Canada] ; Gord Glendon [Canada] ; Peter Devilee [Pays-Bas] ; Caroline Seynaeve [Pays-Bas] ; Maartje J. Hooning [Pays-Bas] ; Margriet Collée [Pays-Bas] ; Angela Cox [Royaume-Uni] ; Simon S. Cross [Royaume-Uni] ; Mitul Shah [Royaume-Uni] ; Robert N. Luben [Royaume-Uni] ; Ute Hamann [Allemagne] ; Diana Torres [Allemagne, Colombie] ; Anna Jakubowska [Pologne] ; Jan Lubinski [Pologne] ; Fergus J. Couch [États-Unis] ; Drakoulis Yannoukakos [Grèce] ; Nick Orr [Royaume-Uni] ; Anthony Swerdlow [Royaume-Uni] ; Hatef Darabi [Suède] ; Jingmei Li [Suède] ; Kamila Czene [Suède] ; Per Hall [Suède] ; Douglas F. Easton [Royaume-Uni] ; Johanna Mattson [Finlande] ; Carl Blomqvist [Finlande] ; Kristiina Aittom Ki [Finlande] ; Heli Nevanlinna [Finlande]

Source :

PLoS ONE [ 1932-6203 ] ; 2016.

RBID : PMC:4858276

Descripteurs français

KwdFr :
- Adulte d'âge moyen, Femelle, Finlande, Haplotypes (génétique), Humains, Hétérozygote, Mutation faux-sens, Mâle, Polymorphisme de nucléotide simple (génétique), Protéines de liaison à l'ADN (génétique), Protéines de liaison à l'ADN (physiologie), Prédisposition génétique à une maladie (génétique), Techniques de génotypage, Tumeurs du sein (génétique), Tumeurs du sein (étiologie).
MESH :
- génétique : Haplotypes, Polymorphisme de nucléotide simple, Protéines de liaison à l'ADN, Prédisposition génétique à une maladie, Tumeurs du sein.
- physiologie : Protéines de liaison à l'ADN.
- étiologie : Tumeurs du sein.
- Adulte d'âge moyen, Femelle, Finlande, Humains, Hétérozygote, Mutation faux-sens, Mâle, Techniques de génotypage.

English descriptors

KwdEn :
- Breast Neoplasms (etiology), Breast Neoplasms (genetics), DNA-Binding Proteins (genetics), DNA-Binding Proteins (physiology), Female, Finland, Genetic Predisposition to Disease (genetics), Genotyping Techniques, Haplotypes (genetics), Heterozygote, Humans, Male, Middle Aged, Mutation, Missense, Polymorphism, Single Nucleotide (genetics).
MESH :
- chemical , genetics : DNA-Binding Proteins.
- etiology : Breast Neoplasms.
- genetics : Breast Neoplasms, Genetic Predisposition to Disease, Haplotypes, Polymorphism, Single Nucleotide.
- chemical , physiology : DNA-Binding Proteins.
- Female, Finland, Genotyping Techniques, Heterozygote, Humans, Male, Middle Aged, Mutation, Missense.

Abstract

Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of RAD51B variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of RAD51B in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and RAD51B haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11–1.19, P = 8.88 x 10⁻¹⁶) and among familial cases (OR: 1.24, 95% CI: 1.16–1.32, P = 6.19 x 10⁻¹¹), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in RAD51B are rare, but common variation at the RAD51B region is significantly associated with familial breast cancer risk.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858276

DOI: 10.1371/journal.pone.0153788
PubMed: 27149063
PubMed Central: 4858276

Affiliations:

Le document en format XML

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 in Familial Breast Cancer</title>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea>
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</nlm:aff>
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<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
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</nlm:aff>
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<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
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</nlm:aff>
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<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
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</nlm:aff>
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<orgName type="university">Université de Cambridge</orgName>
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<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
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</nlm:aff>
<country xml:lang="fr">Australie</country>
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<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="aff016"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Rosenberg, Efraim H" sort="Rosenberg, Efraim H" uniqKey="Rosenberg E" first="Efraim H." last="Rosenberg">Efraim H. Rosenberg</name>
<affiliation wicri:level="3"><nlm:aff id="aff013"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff018"><addr-line>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation wicri:level="3"><nlm:aff id="aff020"><addr-line>Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Oncology, Guy’s Hospital, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation wicri:level="4"><nlm:aff id="aff021"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="2"><nlm:aff id="aff031"><addr-line>Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="2"><nlm:aff id="aff032"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff034"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff035"><addr-line>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="4"><nlm:aff id="aff036"><addr-line>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff037"><addr-line>Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="3"><nlm:aff id="aff034"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff040"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff041"><addr-line>University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation wicri:level="3"><nlm:aff id="aff043"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation wicri:level="3"><nlm:aff id="aff044"><addr-line>Department of Oncology—Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology—Pathology, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Cancer Center, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Cancer Center, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Dyck, Laurien" sort="Van Dyck, Laurien" uniqKey="Van Dyck L" first="Laurien" last="Van Dyck">Laurien Van Dyck</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Vesalius Research Center, VIB, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Vesalius Research Center, VIB, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janssen, Hilde" sort="Janssen, Hilde" uniqKey="Janssen H" first="Hilde" last="Janssen">Hilde Janssen</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff054"><addr-line>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="3"><nlm:aff id="aff055"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="3"><nlm:aff id="aff056"><addr-line>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff057"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="2"><nlm:aff id="aff057"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="4"><nlm:aff id="aff015"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff058"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation wicri:level="4"><nlm:aff id="aff015"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff058"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="aff059"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name>
<affiliation wicri:level="4"><nlm:aff id="aff059"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
<wicri:noRegion>Québec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
<wicri:noRegion>Québec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="3"><nlm:aff id="aff061"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff062"><addr-line>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff063"><addr-line>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<affiliation wicri:level="3"><nlm:aff id="aff061"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff062"><addr-line>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="2"><nlm:aff id="aff064"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation wicri:level="2"><nlm:aff id="aff064"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name>
<affiliation wicri:level="1"><nlm:aff id="aff065"><addr-line>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff067"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="3"><nlm:aff id="aff068"><addr-line>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff069"><addr-line>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="3"><nlm:aff id="aff070"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation wicri:level="3"><nlm:aff id="aff070"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name>
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<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
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<author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
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<author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
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<country xml:lang="fr">Allemagne</country>
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<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
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<country xml:lang="fr">Allemagne</country>
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<affiliation wicri:level="1"><nlm:aff id="aff076"><addr-line>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia</addr-line>
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<country xml:lang="fr">Colombie</country>
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</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
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</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
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</nlm:aff>
<country xml:lang="fr">Pologne</country>
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</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
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</nlm:aff>
<country xml:lang="fr">Grèce</country>
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<placeName><settlement type="city">Athènes</settlement>
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</affiliation>
</author>
<author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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<affiliation wicri:level="3"><nlm:aff id="aff081"><addr-line>Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom</addr-line>
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<author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
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</nlm:aff>
<country xml:lang="fr">Suède</country>
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</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
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</nlm:aff>
<country xml:lang="fr">Suède</country>
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<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
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</nlm:aff>
<country xml:lang="fr">Suède</country>
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<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
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</nlm:aff>
<country xml:lang="fr">Suède</country>
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<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Mattson, Johanna" sort="Mattson, Johanna" uniqKey="Mattson J" first="Johanna" last="Mattson">Johanna Mattson</name>
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<author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
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<country xml:lang="fr">Finlande</country>
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<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>RAD51B</italic>
 in Familial Breast Cancer</title>
<author><name sortKey="Pelttari, Liisa M" sort="Pelttari, Liisa M" uniqKey="Pelttari L" first="Liisa M." last="Pelttari">Liisa M. Pelttari</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</affiliation>
</author>
<author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Vuorela, Mikko" sort="Vuorela, Mikko" uniqKey="Vuorela M" first="Mikko" last="Vuorela">Mikko Vuorela</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Cancer Research and Translational Medicine, Biocenter Oulu, University of Oulu, Oulu</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Kiiski, Johanna I" sort="Kiiski, Johanna I" uniqKey="Kiiski J" first="Johanna I." last="Kiiski">Johanna I. Kiiski</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Vilske, Sara" sort="Vilske, Sara" uniqKey="Vilske S" first="Sara" last="Vilske">Sara Vilske</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</affiliation>
</author>
<author><name sortKey="Nevanlinna, Viivi" sort="Nevanlinna, Viivi" uniqKey="Nevanlinna V" first="Viivi" last="Nevanlinna">Viivi Nevanlinna</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</affiliation>
</author>
<author><name sortKey="Ranta, Salla" sort="Ranta, Salla" uniqKey="Ranta S" first="Salla" last="Ranta">Salla Ranta</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</author>
<author><name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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<affiliation wicri:level="4"><nlm:aff id="aff004"><addr-line>Department of Medical Biochemistry and Genetics, University of Turku, Turku, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Medical Biochemistry and Genetics, University of Turku, Turku</wicri:regionArea>
<placeName><settlement type="city">Turku</settlement>
<region type="région" nuts="2">Finlande occidentale</region>
<settlement type="city">Turku</settlement>
</placeName>
<orgName type="university">Université de Turku</orgName>
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<affiliation wicri:level="3"><nlm:aff id="aff005"><addr-line>Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku, Finland</addr-line>
</nlm:aff>
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<wicri:regionArea>Tyks Microbiology and Genetics, Department of Medical Genetics, Turku University Hospital, Turku</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
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</nlm:aff>
<country xml:lang="fr">Finlande</country>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff006"><addr-line>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kallioniemi, Anne" sort="Kallioniemi, Anne" uniqKey="Kallioniemi A" first="Anne" last="Kallioniemi">Anne Kallioniemi</name>
<affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>BioMediTech, University of Tampere, Tampere, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>BioMediTech, University of Tampere, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Fimlab Laboratories, Tampere, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Fimlab Laboratories, Tampere</wicri:regionArea>
<wicri:noRegion>Tampere</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
<affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Gynaecology Research Unit, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Gynaecology Research Unit, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<affiliation wicri:level="3"><nlm:aff id="aff009"><addr-line>Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Radiation Oncology Research Unit, Hannover Medical School, Hannover</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="2"><nlm:aff id="aff010"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
<affiliation wicri:level="3"><nlm:aff id="aff013"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name>
<affiliation wicri:level="2"><nlm:aff id="aff010"><addr-line>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff014"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="aff015"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="aff016"><addr-line>Department of Pathology, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Pathology, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="Rosenberg, Efraim H" sort="Rosenberg, Efraim H" uniqKey="Rosenberg E" first="Efraim H." last="Rosenberg">Efraim H. Rosenberg</name>
<affiliation wicri:level="3"><nlm:aff id="aff013"><addr-line>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff018"><addr-line>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>David Geffen School of Medicine, Department of Medicine, Division of Hematology and Oncology, University of California Los Angeles, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<affiliation wicri:level="3"><nlm:aff id="aff017"><addr-line>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen</wicri:regionArea>
<placeName><settlement type="city">Erlangen</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Moyenne-Franconie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation wicri:level="3"><nlm:aff id="aff019"><addr-line>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<affiliation wicri:level="3"><nlm:aff id="aff020"><addr-line>Research Oncology, Guy’s Hospital, King's College London, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Research Oncology, Guy’s Hospital, King's College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<affiliation wicri:level="4"><nlm:aff id="aff021"><addr-line>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name>
<affiliation wicri:level="3"><nlm:aff id="aff022"><addr-line>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff023"><addr-line>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<affiliation wicri:level="1"><nlm:aff id="aff024"><addr-line>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Environmental Epidemiology of Cancer, Center for Research in Epidemiology and Population Health, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff025"><addr-line>University Paris-Sud, Villejuif, France</addr-line>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University Paris-Sud, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<affiliation wicri:level="1"><nlm:aff id="aff026"><addr-line>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen General Population Study, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation wicri:level="1"><nlm:aff id="aff027"><addr-line>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Herlev</wicri:regionArea>
<wicri:noRegion>Herlev</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff028"><addr-line>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark</addr-line>
</nlm:aff>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen</wicri:regionArea>
<placeName><settlement type="city">Copenhague</settlement>
<region type="région" nuts="2">Hovedstaden</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff030"><addr-line>Centro de Investigación en Red de Enfermedades Raras, Valencia, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigación en Red de Enfermedades Raras, Valencia</wicri:regionArea>
<wicri:noRegion>Valencia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
<affiliation wicri:level="3"><nlm:aff id="aff029"><addr-line>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain</addr-line>
</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<affiliation wicri:level="2"><nlm:aff id="aff031"><addr-line>Beckman Research Institute of City of Hope, Duarte, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Beckman Research Institute of City of Hope, Duarte, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<affiliation wicri:level="2"><nlm:aff id="aff032"><addr-line>Department of Epidemiology, University of California Irvine, Irvine, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of California Irvine, Irvine, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff034"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff035"><addr-line>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<affiliation wicri:level="3"><nlm:aff id="aff033"><addr-line>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="4"><nlm:aff id="aff036"><addr-line>Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Gynaecology and Obstetrics, Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="aff037"><addr-line>Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Hereditary Breast and Ovarian Cancer, University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff038"><addr-line>Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Integrated Oncology (CIO), University Hospital of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff039"><addr-line>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<affiliation wicri:level="3"><nlm:aff id="aff034"><addr-line>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff040"><addr-line>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Stuttgart</region>
<settlement type="city">Stuttgart</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff041"><addr-line>University of Tübingen, Tübingen, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Tübingen, Tübingen</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
<settlement type="city">Tübingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<affiliation wicri:level="1"><nlm:aff id="aff042"><addr-line>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum, Bochum</wicri:regionArea>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
<wicri:noRegion>Bochum</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
<affiliation wicri:level="3"><nlm:aff id="aff043"><addr-line>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
<affiliation wicri:level="3"><nlm:aff id="aff044"><addr-line>Department of Oncology—Pathology, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Oncology—Pathology, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Cancer Center, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name>
<affiliation wicri:level="1"><nlm:aff id="aff045"><addr-line>Cancer Center, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Cancer Center, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff046"><addr-line>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff047"><addr-line>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio</wicri:regionArea>
<wicri:noRegion>Kuopio</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation wicri:level="1"><nlm:aff id="aff048"><addr-line>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Dyck, Laurien" sort="Van Dyck, Laurien" uniqKey="Van Dyck L" first="Laurien" last="Van Dyck">Laurien Van Dyck</name>
<affiliation wicri:level="1"><nlm:aff id="aff050"><addr-line>Vesalius Research Center, VIB, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Vesalius Research Center, VIB, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff051"><addr-line>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janssen, Hilde" sort="Janssen, Hilde" uniqKey="Janssen H" first="Hilde" last="Janssen">Hilde Janssen</name>
<affiliation wicri:level="1"><nlm:aff id="aff052"><addr-line>Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium</addr-line>
</nlm:aff>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Leuven Multidisciplinary Breast Center, Leuven Cancer Institute, University Hospitals Leuven, Leuven</wicri:regionArea>
<wicri:noRegion>Leuven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff054"><addr-line>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea>
<placeName><settlement type="city">Hambourg</settlement>
<region type="land" nuts="2">Hambourg</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<affiliation wicri:level="3"><nlm:aff id="aff053"><addr-line>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation wicri:level="3"><nlm:aff id="aff055"><addr-line>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation wicri:level="3"><nlm:aff id="aff056"><addr-line>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan, Italy</addr-line>
</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>IFOM, Fondazione Istituto FIRC (Italian Foundation of Cancer Research) di Oncologia Molecolare, Milan</wicri:regionArea>
<placeName><settlement type="city">Milan</settlement>
<region nuts="2">Lombardie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name>
<affiliation wicri:level="2"><nlm:aff id="aff057"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<affiliation wicri:level="2"><nlm:aff id="aff057"><addr-line>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="4"><nlm:aff id="aff015"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff058"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<affiliation wicri:level="4"><nlm:aff id="aff015"><addr-line>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global health, The University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff058"><addr-line>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</addr-line>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="aff059"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name>
<affiliation wicri:level="4"><nlm:aff id="aff059"><addr-line>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
<wicri:noRegion>Québec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation wicri:level="1"><nlm:aff id="aff060"><addr-line>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City</wicri:regionArea>
<wicri:noRegion>Québec City</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<affiliation wicri:level="3"><nlm:aff id="aff061"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff062"><addr-line>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff063"><addr-line>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<affiliation wicri:level="3"><nlm:aff id="aff061"><addr-line>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff062"><addr-line>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway</addr-line>
</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>K.G. Jebsen Center for Breast Cancer Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo</wicri:regionArea>
<placeName><settlement type="city">Oslo</settlement>
<region nuts="2">Østlandet</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="2"><nlm:aff id="aff064"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<affiliation wicri:level="2"><nlm:aff id="aff064"><addr-line>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee</wicri:regionArea>
<placeName><region type="state">Tennessee</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name>
<affiliation wicri:level="1"><nlm:aff id="aff065"><addr-line>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Surgery, Oulu University Hospital, University of Oulu, Oulu</wicri:regionArea>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff067"><addr-line>Department of Molecular Genetics, University of Toronto, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Molecular Genetics, University of Toronto, Toronto</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
<affiliation wicri:level="1"><nlm:aff id="aff066"><addr-line>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</addr-line>
</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<affiliation wicri:level="3"><nlm:aff id="aff068"><addr-line>Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Pathology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff069"><addr-line>Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
<affiliation wicri:level="3"><nlm:aff id="aff070"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<affiliation wicri:level="3"><nlm:aff id="aff070"><addr-line>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name>
<affiliation wicri:level="3"><nlm:aff id="aff071"><addr-line>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands</addr-line>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<affiliation wicri:level="1"><nlm:aff id="aff072"><addr-line>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<affiliation wicri:level="1"><nlm:aff id="aff073"><addr-line>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield</wicri:regionArea>
<wicri:noRegion>Sheffield</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name>
<affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name>
<affiliation wicri:level="4"><nlm:aff id="aff074"><addr-line>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Gerontology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation wicri:level="3"><nlm:aff id="aff075"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
<affiliation wicri:level="3"><nlm:aff id="aff075"><addr-line>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany</addr-line>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff076"><addr-line>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota, Colombia</addr-line>
</nlm:aff>
<country xml:lang="fr">Colombie</country>
<wicri:regionArea>Institute of Human Genetics, Pontificia Universidad Javeriana, Bogota</wicri:regionArea>
<wicri:noRegion>Bogota</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation wicri:level="1"><nlm:aff id="aff077"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation wicri:level="1"><nlm:aff id="aff077"><addr-line>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland</addr-line>
</nlm:aff>
<country xml:lang="fr">Pologne</country>
<wicri:regionArea>Department of Genetics and Pathology, Pomeranian Medical University, Szczecin</wicri:regionArea>
<wicri:noRegion>Szczecin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<affiliation wicri:level="2"><nlm:aff id="aff078"><addr-line>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
<affiliation wicri:level="3"><nlm:aff id="aff079"><addr-line>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece</addr-line>
</nlm:aff>
<country xml:lang="fr">Grèce</country>
<wicri:regionArea>Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens</wicri:regionArea>
<placeName><settlement type="city">Athènes</settlement>
<region nuts="2" type="region">Attique (région)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name>
<affiliation wicri:level="3"><nlm:aff id="aff080"><addr-line>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<affiliation wicri:level="3"><nlm:aff id="aff014"><addr-line>Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Genetics and Epidemiology, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="aff081"><addr-line>Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Division of Breast Cancer Research, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
<affiliation wicri:level="3"><nlm:aff id="aff082"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<affiliation wicri:level="3"><nlm:aff id="aff082"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="3"><nlm:aff id="aff082"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="3"><nlm:aff id="aff082"><addr-line>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden</addr-line>
</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="4"><nlm:aff id="aff011"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff012"><addr-line>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom</addr-line>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mattson, Johanna" sort="Mattson, Johanna" uniqKey="Mattson J" first="Johanna" last="Mattson">Johanna Mattson</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<affiliation wicri:level="1"><nlm:aff id="aff083"><addr-line>Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Oncology, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1"><nlm:aff id="aff084"><addr-line>Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Clinical Genetics, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland</addr-line>
</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (etiology)</term>
<term>Breast Neoplasms (genetics)</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>DNA-Binding Proteins (physiology)</term>
<term>Female</term>
<term>Finland</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Genotyping Techniques</term>
<term>Haplotypes (genetics)</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation, Missense</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Finlande</term>
<term>Haplotypes (génétique)</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mutation faux-sens</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple (génétique)</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Protéines de liaison à l'ADN (physiologie)</term>
<term>Prédisposition génétique à une maladie (génétique)</term>
<term>Techniques de génotypage</term>
<term>Tumeurs du sein (génétique)</term>
<term>Tumeurs du sein (étiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
<term>Genetic Predisposition to Disease</term>
<term>Haplotypes</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Haplotypes</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Protéines de liaison à l'ADN</term>
<term>Prédisposition génétique à une maladie</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Protéines de liaison à l'ADN</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Finland</term>
<term>Genotyping Techniques</term>
<term>Heterozygote</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation, Missense</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Femelle</term>
<term>Finlande</term>
<term>Humains</term>
<term>Hétérozygote</term>
<term>Mutation faux-sens</term>
<term>Mâle</term>
<term>Techniques de génotypage</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p>Common variation on 14q24.1, close to <italic>RAD51B</italic>
, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study was to investigate the role of <italic>RAD51B</italic>
 variants in breast cancer predisposition, particularly in the context of familial breast cancer in Finland. We sequenced the coding region of <italic>RAD51B</italic>
 in 168 Finnish breast cancer patients from the Helsinki region for identification of possible recurrent founder mutations. In addition, we studied the known rs999737, rs2588809, and rs1314913 SNPs and <italic>RAD51B</italic>
 haplotypes in 44,791 breast cancer cases and 43,583 controls from 40 studies participating in the Breast Cancer Association Consortium (BCAC) that were genotyped on a custom chip (iCOGS). We identified one putatively pathogenic missense mutation c.541C>T among the Finnish cancer patients and subsequently genotyped the mutation in additional breast cancer cases (n = 5259) and population controls (n = 3586) from Finland and Belarus. No significant association with breast cancer risk was seen in the meta-analysis of the Finnish datasets or in the large BCAC dataset. The association with previously identified risk variants rs999737, rs2588809, and rs1314913 was replicated among all breast cancer cases and also among familial cases in the BCAC dataset. The most significant association was observed for the haplotype carrying the risk-alleles of all the three SNPs both among all cases (odds ratio (OR): 1.15, 95% confidence interval (CI): 1.11–1.19, <italic>P</italic>
 = 8.88 x 10<sup>−16</sup>
) and among familial cases (OR: 1.24, 95% CI: 1.16–1.32, <italic>P</italic>
 = 6.19 x 10<sup>−11</sup>
), compared to the haplotype with the respective protective alleles. Our results suggest that loss-of-function mutations in <italic>RAD51B</italic>
 are rare, but common variation at the <italic>RAD51B</italic>
 region is significantly associated with familial breast cancer risk.</p>
</div>
</front>
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<author><name sortKey="Garcia Closas, M" uniqKey="Garcia Closas M">M Garcia-Closas</name>
</author>
<author><name sortKey="Humphreys, M" uniqKey="Humphreys M">M Humphreys</name>
</author>
<author><name sortKey="Platte, R" uniqKey="Platte R">R Platte</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
<author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Golmard, L" uniqKey="Golmard L">L Golmard</name>
</author>
<author><name sortKey="Caux Moncoutier, V" uniqKey="Caux Moncoutier V">V Caux-Moncoutier</name>
</author>
<author><name sortKey="Davy, G" uniqKey="Davy G">G Davy</name>
</author>
<author><name sortKey="Al Ageeli, E" uniqKey="Al Ageeli E">E Al Ageeli</name>
</author>
<author><name sortKey="Poirot, B" uniqKey="Poirot B">B Poirot</name>
</author>
<author><name sortKey="Tirapo, C" uniqKey="Tirapo C">C Tirapo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wadt, Ka" uniqKey="Wadt K">KA Wadt</name>
</author>
<author><name sortKey="Aoude, Lg" uniqKey="Aoude L">LG Aoude</name>
</author>
<author><name sortKey="Golmard, L" uniqKey="Golmard L">L Golmard</name>
</author>
<author><name sortKey="Hansen, Tv" uniqKey="Hansen T">TV Hansen</name>
</author>
<author><name sortKey="Sastre Garau, X" uniqKey="Sastre Garau X">X Sastre-Garau</name>
</author>
<author><name sortKey="Hayward, Nk" uniqKey="Hayward N">NK Hayward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, H" uniqKey="Song H">H Song</name>
</author>
<author><name sortKey="Dicks, E" uniqKey="Dicks E">E Dicks</name>
</author>
<author><name sortKey="Ramus, Sj" uniqKey="Ramus S">SJ Ramus</name>
</author>
<author><name sortKey="Tyrer, Jp" uniqKey="Tyrer J">JP Tyrer</name>
</author>
<author><name sortKey="Intermaggio, Mp" uniqKey="Intermaggio M">MP Intermaggio</name>
</author>
<author><name sortKey="Hayward, J" uniqKey="Hayward J">J Hayward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, J" uniqKey="Johnson J">J Johnson</name>
</author>
<author><name sortKey="Healey, S" uniqKey="Healey S">S Healey</name>
</author>
<author><name sortKey="Khanna, Kk" uniqKey="Khanna K">KK Khanna</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Belgique</li>
<li>Canada</li>
<li>Colombie</li>
<li>Danemark</li>
<li>Espagne</li>
<li>Finlande</li>
<li>France</li>
<li>Grèce</li>
<li>Italie</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Pologne</li>
<li>Royaume-Uni</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Attique (région)</li>
<li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>Californie</li>
<li>Communauté de Madrid</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>District de Moyenne-Franconie</li>
<li>District de Stuttgart</li>
<li>District de Tübingen</li>
<li>Finlande occidentale</li>
<li>Grand Londres</li>
<li>Hambourg</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Hovedstaden</li>
<li>Lombardie</li>
<li>Maryland</li>
<li>Minnesota</li>
<li>Ontario</li>
<li>Oxfordshire</li>
<li>Svealand</li>
<li>Tennessee</li>
<li>Victoria (État)</li>
<li>Østlandet</li>
</region>
<settlement><li>Amsterdam</li>
<li>Athènes</li>
<li>Cambridge</li>
<li>Copenhague</li>
<li>Erlangen</li>
<li>Hambourg</li>
<li>Hanovre</li>
<li>Heidelberg</li>
<li>Leyde</li>
<li>Londres</li>
<li>Los Angeles</li>
<li>Madrid</li>
<li>Melbourne</li>
<li>Milan</li>
<li>Munich</li>
<li>Oslo</li>
<li>Oxford</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Stuttgart</li>
<li>Toronto</li>
<li>Turku</li>
<li>Tübingen</li>
</settlement>
<orgName><li>Université d'Oxford</li>
<li>Université de Californie du Sud</li>
<li>Université de Cambridge</li>
<li>Université de Melbourne</li>
<li>Université de Toronto</li>
<li>Université de Turku</li>
<li>Université technique de Munich</li>
</orgName>
</list>
<tree><country name="Finlande"><noRegion><name sortKey="Pelttari, Liisa M" sort="Pelttari, Liisa M" uniqKey="Pelttari L" first="Liisa M." last="Pelttari">Liisa M. Pelttari</name>
</noRegion>
<name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<name sortKey="Blomqvist, Carl" sort="Blomqvist, Carl" uniqKey="Blomqvist C" first="Carl" last="Blomqvist">Carl Blomqvist</name>
<name sortKey="Grip, Mervi" sort="Grip, Mervi" uniqKey="Grip M" first="Mervi" last="Grip">Mervi Grip</name>
<name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name>
<name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name>
<name sortKey="Hartikainen, Jaana M" sort="Hartikainen, Jaana M" uniqKey="Hartikainen J" first="Jaana M." last="Hartikainen">Jaana M. Hartikainen</name>
<name sortKey="Kallioniemi, Anne" sort="Kallioniemi, Anne" uniqKey="Kallioniemi A" first="Anne" last="Kallioniemi">Anne Kallioniemi</name>
<name sortKey="Kallioniemi, Anne" sort="Kallioniemi, Anne" uniqKey="Kallioniemi A" first="Anne" last="Kallioniemi">Anne Kallioniemi</name>
<name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<name sortKey="Kiiski, Johanna I" sort="Kiiski, Johanna I" uniqKey="Kiiski J" first="Johanna I." last="Kiiski">Johanna I. Kiiski</name>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<name sortKey="Mannermaa, Arto" sort="Mannermaa, Arto" uniqKey="Mannermaa A" first="Arto" last="Mannermaa">Arto Mannermaa</name>
<name sortKey="Mattson, Johanna" sort="Mattson, Johanna" uniqKey="Mattson J" first="Johanna" last="Mattson">Johanna Mattson</name>
<name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<name sortKey="Nevanlinna, Viivi" sort="Nevanlinna, Viivi" uniqKey="Nevanlinna V" first="Viivi" last="Nevanlinna">Viivi Nevanlinna</name>
<name sortKey="Ranta, Salla" sort="Ranta, Salla" uniqKey="Ranta S" first="Salla" last="Ranta">Salla Ranta</name>
<name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
<name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
<name sortKey="Schleutker, Johanna" sort="Schleutker, Johanna" uniqKey="Schleutker J" first="Johanna" last="Schleutker">Johanna Schleutker</name>
<name sortKey="Vilske, Sara" sort="Vilske, Sara" uniqKey="Vilske S" first="Sara" last="Vilske">Sara Vilske</name>
<name sortKey="Vuorela, Mikko" sort="Vuorela, Mikko" uniqKey="Vuorela M" first="Mikko" last="Vuorela">Mikko Vuorela</name>
<name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
<name sortKey="Winqvist, Robert" sort="Winqvist, Robert" uniqKey="Winqvist R" first="Robert" last="Winqvist">Robert Winqvist</name>
</country>
<country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Dork, Thilo" sort="Dork, Thilo" uniqKey="Dork T" first="Thilo" last="Dörk">Thilo Dörk</name>
</region>
<name sortKey="Arndt, Volker" sort="Arndt, Volker" uniqKey="Arndt V" first="Volker" last="Arndt">Volker Arndt</name>
<name sortKey="Beckmann, Matthias W" sort="Beckmann, Matthias W" uniqKey="Beckmann M" first="Matthias W." last="Beckmann">Matthias W. Beckmann</name>
<name sortKey="Bogdanova, Natalia V" sort="Bogdanova, Natalia V" uniqKey="Bogdanova N" first="Natalia V." last="Bogdanova">Natalia V. Bogdanova</name>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<name sortKey="Brauch, Hiltrud" sort="Brauch, Hiltrud" uniqKey="Brauch H" first="Hiltrud" last="Brauch">Hiltrud Brauch</name>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
<name sortKey="Bruning, Thomas" sort="Bruning, Thomas" uniqKey="Bruning T" first="Thomas" last="Brüning">Thomas Brüning</name>
<name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<name sortKey="Burwinkel, Barbara" sort="Burwinkel, Barbara" uniqKey="Burwinkel B" first="Barbara" last="Burwinkel">Barbara Burwinkel</name>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<name sortKey="Rudolph, Anja" sort="Rudolph, Anja" uniqKey="Rudolph A" first="Anja" last="Rudolph">Anja Rudolph</name>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name>
<name sortKey="Surowy, Harald" sort="Surowy, Harald" uniqKey="Surowy H" first="Harald" last="Surowy">Harald Surowy</name>
<name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
</country>
<country name="États-Unis"><region name="Maryland"><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
</region>
<name sortKey="Anton Culver, Hoda" sort="Anton Culver, Hoda" uniqKey="Anton Culver H" first="Hoda" last="Anton-Culver">Hoda Anton-Culver</name>
<name sortKey="Beeghly Fadiel, Alicia" sort="Beeghly Fadiel, Alicia" uniqKey="Beeghly Fadiel A" first="Alicia" last="Beeghly-Fadiel">Alicia Beeghly-Fadiel</name>
<name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name>
<name sortKey="Fasching, Peter A" sort="Fasching, Peter A" uniqKey="Fasching P" first="Peter A." last="Fasching">Peter A. Fasching</name>
<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name>
<name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<name sortKey="Hallberg, Emily" sort="Hallberg, Emily" uniqKey="Hallberg E" first="Emily" last="Hallberg">Emily Hallberg</name>
<name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name>
<name sortKey="Olson, Janet E" sort="Olson, Janet E" uniqKey="Olson J" first="Janet E." last="Olson">Janet E. Olson</name>
<name sortKey="Schumacher, Fredrick" sort="Schumacher, Fredrick" uniqKey="Schumacher F" first="Fredrick" last="Schumacher">Fredrick Schumacher</name>
<name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
</region>
<name sortKey="Bolla, Manjeet K" sort="Bolla, Manjeet K" uniqKey="Bolla M" first="Manjeet K." last="Bolla">Manjeet K. Bolla</name>
<name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name>
<name sortKey="Cross, Simon S" sort="Cross, Simon S" uniqKey="Cross S" first="Simon S." last="Cross">Simon S. Cross</name>
<name sortKey="Dennis, Joe" sort="Dennis, Joe" uniqKey="Dennis J" first="Joe" last="Dennis">Joe Dennis</name>
<name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<name sortKey="Dunning, Alison M" sort="Dunning, Alison M" uniqKey="Dunning A" first="Alison M." last="Dunning">Alison M. Dunning</name>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="García-Closas">Montserrat García-Closas</name>
<name sortKey="Luben, Robert N" sort="Luben, Robert N" uniqKey="Luben R" first="Robert N." last="Luben">Robert N. Luben</name>
<name sortKey="Michailidou, Kyriaki" sort="Michailidou, Kyriaki" uniqKey="Michailidou K" first="Kyriaki" last="Michailidou">Kyriaki Michailidou</name>
<name sortKey="Orr, Nick" sort="Orr, Nick" uniqKey="Orr N" first="Nick" last="Orr">Nick Orr</name>
<name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D. P." last="Pharoah">Paul D. P. Pharoah</name>
<name sortKey="Sawyer, Elinor J" sort="Sawyer, Elinor J" uniqKey="Sawyer E" first="Elinor J." last="Sawyer">Elinor J. Sawyer</name>
<name sortKey="Shah, Mitul" sort="Shah, Mitul" uniqKey="Shah M" first="Mitul" last="Shah">Mitul Shah</name>
<name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<name sortKey="Swerdlow, Anthony" sort="Swerdlow, Anthony" uniqKey="Swerdlow A" first="Anthony" last="Swerdlow">Anthony Swerdlow</name>
<name sortKey="Tomlinson, Ian" sort="Tomlinson, Ian" uniqKey="Tomlinson I" first="Ian" last="Tomlinson">Ian Tomlinson</name>
<name sortKey="Wang, Qin" sort="Wang, Qin" uniqKey="Wang Q" first="Qin" last="Wang">Qin Wang</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Schmidt, Marjanka K" sort="Schmidt, Marjanka K" uniqKey="Schmidt M" first="Marjanka K." last="Schmidt">Marjanka K. Schmidt</name>
</region>
<name sortKey="Collee, Margriet" sort="Collee, Margriet" uniqKey="Collee M" first="Margriet" last="Collée">Margriet Collée</name>
<name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name>
<name sortKey="Hooning, Maartje J" sort="Hooning, Maartje J" uniqKey="Hooning M" first="Maartje J." last="Hooning">Maartje J. Hooning</name>
<name sortKey="Rosenberg, Efraim H" sort="Rosenberg, Efraim H" uniqKey="Rosenberg E" first="Efraim H." last="Rosenberg">Efraim H. Rosenberg</name>
<name sortKey="Seynaeve, Caroline" sort="Seynaeve, Caroline" uniqKey="Seynaeve C" first="Caroline" last="Seynaeve">Caroline Seynaeve</name>
</country>
<country name="Australie"><region name="Victoria (État)"><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
</region>
<name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L." last="Milne">Roger L. Milne</name>
<name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
</country>
<country name="France"><noRegion><name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
</noRegion>
<name sortKey="Guenel, Pascal" sort="Guenel, Pascal" uniqKey="Guenel P" first="Pascal" last="Guénel">Pascal Guénel</name>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
<name sortKey="Truong, Therese" sort="Truong, Therese" uniqKey="Truong T" first="Thérèse" last="Truong">Thérèse Truong</name>
</country>
<country name="Danemark"><noRegion><name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
</noRegion>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<name sortKey="Bojesen, Stig E" sort="Bojesen, Stig E" uniqKey="Bojesen S" first="Stig E." last="Bojesen">Stig E. Bojesen</name>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
<name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G." last="Nordestgaard">B Rge G. Nordestgaard</name>
</country>
<country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
</region>
<name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<name sortKey="Gonzalez Neira, Anna" sort="Gonzalez Neira, Anna" uniqKey="Gonzalez Neira A" first="Anna" last="González-Neira">Anna González-Neira</name>
</country>
<country name="Suède"><region name="Svealand"><name sortKey="Lindblom, Annika" sort="Lindblom, Annika" uniqKey="Lindblom A" first="Annika" last="Lindblom">Annika Lindblom</name>
</region>
<name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<name sortKey="Darabi, Hatef" sort="Darabi, Hatef" uniqKey="Darabi H" first="Hatef" last="Darabi">Hatef Darabi</name>
<name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<name sortKey="Li, Jingmei" sort="Li, Jingmei" uniqKey="Li J" first="Jingmei" last="Li">Jingmei Li</name>
<name sortKey="Margolin, Sara" sort="Margolin, Sara" uniqKey="Margolin S" first="Sara" last="Margolin">Sara Margolin</name>
</country>
<country name="Belgique"><noRegion><name sortKey="Van Dyck, Laurien" sort="Van Dyck, Laurien" uniqKey="Van Dyck L" first="Laurien" last="Van Dyck">Laurien Van Dyck</name>
</noRegion>
<name sortKey="Janssen, Hilde" sort="Janssen, Hilde" uniqKey="Janssen H" first="Hilde" last="Janssen">Hilde Janssen</name>
<name sortKey="Van Dyck, Laurien" sort="Van Dyck, Laurien" uniqKey="Van Dyck L" first="Laurien" last="Van Dyck">Laurien Van Dyck</name>
</country>
<country name="Italie"><region name="Lombardie"><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
</region>
<name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
</country>
<country name="Canada"><noRegion><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
</noRegion>
<name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name>
<name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name>
</country>
<country name="Norvège"><region name="Østlandet"><name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
</region>
<name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<name sortKey="Borresen Dale, Anne Lise" sort="Borresen Dale, Anne Lise" uniqKey="Borresen Dale A" first="Anne-Lise" last="Borresen-Dale">Anne-Lise Borresen-Dale</name>
<name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
<name sortKey="Kristensen, Vessela" sort="Kristensen, Vessela" uniqKey="Kristensen V" first="Vessela" last="Kristensen">Vessela Kristensen</name>
</country>
<country name="Colombie"><noRegion><name sortKey="Torres, Diana" sort="Torres, Diana" uniqKey="Torres D" first="Diana" last="Torres">Diana Torres</name>
</noRegion>
</country>
<country name="Pologne"><noRegion><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
</noRegion>
<name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
</country>
<country name="Grèce"><region name="Attique (région)"><name sortKey="Yannoukakos, Drakoulis" sort="Yannoukakos, Drakoulis" uniqKey="Yannoukakos D" first="Drakoulis" last="Yannoukakos">Drakoulis Yannoukakos</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002503 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002503 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:4858276
   |texte=   RAD51B in Familial Breast Cancer
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:27149063" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a AustralieFrV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

RAD51B in Familial Breast Cancer

RAD51B in Familial Breast Cancer

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.